Any time of day should be fine. I think if I take them in the late morning, I feel a bit better that afternoon and evening. But I usually take them in the evening, and they still help a lot in lifting the headache and malaise and slowness and un-alertness that would otherwise be so prominent.

The gelcaps I take are 300mg per capsule, of 80% silymarin, for dose reference. One per day of that size is plenty.

Crossing my fingers it will help you.